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What Is PML?

PML Facts

  • PML - or progressive multifocal leukoencephalopathy - is a devastating disease that generally leads to permanent neurological damage, severe disability, or death.

  • PML is caused by reactivation of the JC virus, which is quite common in the general population but almost always kept in check by healthy immune systems.

  • If a person's immune system is weakened by either disease or immunosuppressant medication, JC virus may replicate and lead to PML.

  • There is no cure for PML, and making a diagnosis is difficult.

PREVENTION is the best defense against PML.

Who is at Risk for PML

  • Most PML cases today are linked to medications used to treat multiple sclerosis and a variety of cancers. A comprehensive list of PML-linked treatments can be found in the table below.

  • PML can also result from immune suppression caused by HIV/AIDS, leukemias, and other immunocompromising conditions.

Medications Linked to PML

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Gray shading indicates drugs with Black Box Warnings for PML in their prescribing information, the strongest warning that the FDA requires. Tables last updated on 9/16/2022. Please note that some PML-linked treatments may not be represented in these tables.

If you are prescribed an immunosuppressive drug or have an immunocompromising condition, KNOW YOUR PML RISK.

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